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Symbol
Name
ID 		Dkc1
dyskeratosis congenita 1, dyskerin
MGI:1861727
Phenotype annotations related to hematopoietic system
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Bone marrow hypocellularity
Pancytopenia
Aplastic anemia
Anemia
Leukopenia
Abnormality of neutrophils
Acute myeloid leukemia
Abnormality of coagulation
Thrombocytopenia
Lymphoma
Hodgkin lymphoma
Myelodysplasia
Splenomegaly
Disease(s) Associated with DKC1
aplastic anemia
dyskeratosis congenita
X-linked dyskeratosis congenita

Mouse Phenotypes
hematopoietic system phenotype
decreased hematopoietic stem cell proliferation
enlarged spleen
abnormal hematopoietic system morphology/development
abnormal definitive hematopoiesis
decreased common myeloid progenitor cell number
extramedullary hematopoiesis
anemia
abnormal bone marrow cell morphology/development
decreased bone marrow cell number
decreased erythroid progenitor cell number
abnormal erythrocyte morphology
decreased hemoglobin content
thrombocytopenia
decreased B cell number
decreased pre-B cell number
decreased T cell number
decreased lymphocyte cell number
decreased leukocyte cell number
abnormal spleen morphology
decreased spleen red pulp amount
decreased spleen white pulp amount
abnormal hematopoietic system physiology
abnormal bone marrow cell physiology
Availability Mouse Genotype
Dkc1tm1.1Pjma/Dkc1+
Dkc1tm1Ppp/Dkc1+
Dkc1tm1.1Pjma/Y *
Dkc1tm1Ppp/Y
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory